Homeostatic imbalance that causes diabetes for a teenager

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Homeostatic imbalance that causes diabetes for a teenager

Received Mar 17; Accepted Jun This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Homeostatic imbalance that causes diabetes for a teenager

Childhood obesity is associated with an increased risk for insulin resistance. The underlying mechanism for the physiological increase in insulin levels in puberty is not clearly understood.

Two hundred and eight obese children and adolescents girls, boys aged between 5 and 18 years were included in the study. The children were divided into prepubertal and pubertal groups. A standard oral glucose tolerance test OGTT was carried out in all children.

The development of type 2 diabetes mellitus is induced by the decreased insulin sensitivity, which leads to increased insulin production. This imbalance causes a predisposition to several metabolic disorders such as early atherosclerosis, progressive obesity, canthosis nigricans, increase in skin tags, hypertension, dyslipidemia, fatty liver and polycystic ovarian syndrome 5.

Obesity and insulin resistance, previously considered as a problem of older ages, are becoming serious issue also in the pediatric age group. Early detection of insulin resistance is important for prevention of these complications.

Various methods to define insulin sensitivity have been developed. Among other models, euglycemic clamp and modified minimal model are considered to be gold standards. However, they are complex and invasive tests, which can be used for research purposes only 67.

However, the use of OGTT in large populations is limited.

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Studies have shown that a physiological transient insulin resistance develops in the pubertal period although its cause is not fully understood. It is known that the frequency of insulin resistance varies between genders and also among races 1516171819 METHODS Two hundred and sixty eight obese children and adolescents girls, boys aged between 5 and 18 years were included in the study.

The children included in the study had normal thyroid function tests and morning fasting cortisol levels. Parental consent was taken for additional blood sampling to determine insulin levels.

Body mass index BMI of the patients was calculated using the equation: Subjects, whose BMI values were above the 95th percentile of the BMI reference curve adjusted to Turkish children according to age and gender, were accepted as obese Detailed history was taken from the parents, and the subjects underwent a detailed physical examination and pubertal evaluation performed by the same pediatric endocrinologist.

A testicular volume equal to or greater than 4 ml in boys and onset of breast development in girls were accepted as the criteria for onset of puberty. OGTT was carried out in order to determine insulin resistance.

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This method was first introduced by Maruhama at al Dec 16,  · It causes bicarbonaturia and a mild degree of hyperchloremic metabolic acidosis There have also been reports of symptomatic anion gap metabolic acidosis associated with acetazolamide therapy in elderly patients 26 and in those with impaired renal function 26, 27 and diabetes mellitus Jul 22,  · Earlier this year, the realms of law and new media collided when Lori Drew was hit with federal charges for creating a fake MySpace page and harassing a neighboring teenager, who then committed.

The endocrine system is a network of glands that produce and release hormones that help control many important body functions, including the body's ability to change calories into energy that. Acute kidney injury is characterized by abrupt deterioration in kidney function, manifested by an increase in serum creatinine level with or without reduced urine output.

Homeostatic Imbalance - Hypercalcemia is a condition where there is sustained high blood calcium levels.

This leads to deposits of calcium salts in the blood vessels, kidneys, and soft organs - . Introduction.

Homeostatic imbalance that causes diabetes for a teenager

Homeostasis is derived from a Greek word that means to stand equally. Homeostasis is a hormonal process whereby the body balances the internal environment in order to ensure all the body parts are working properly and normally.

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